Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 6/20 | 0.46 |
| ▸ | MMP9 | P14780 | 4/20 | 0.46 |
| ▸ | MMP3 | P08254 | 3/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10420790 | 0.91 | MMP2 (0.50) | KMT2AALDH1A1MMP2MMP9MMP3 | |
| SCHEMBL10419243 | 0.91 | MMP2 (0.50) | KMT2AALDH1A1MMP2MMP9MMP3 | |
| SCHEMBL10419718 | 0.91 | MMP2 (0.50) | KMT2AALDH1A1MMP2MMP9MMP3 | |
| SCHEMBL10420376 | 0.90 | MMP2 (0.51) | KMT2AALDH1A1MMP2MMP9MMP3 | |
| SCHEMBL10420440 | 0.89 | MMP2 (0.54) | ALDH1A1MMP2MMP9MMP3MMP13 | |
| SCHEMBL10420884 | 0.89 | MMP2 (0.54) | ALDH1A1MMP2MMP9MMP3MMP13 | |
| SCHEMBL10419465 | 0.89 | MMP2 (0.54) | ALDH1A1MMP2MMP9MMP3MMP13 | |
| SCHEMBL10420695 | 0.87 | MMP2 (0.55) | ALDH1A1MMP2MMP9MMP3MMP13 | |
| SCHEMBL9814905 | 0.86 | TBXAS1 (0.56) | MMP2MMP9TBXAS1 | |
| SCHEMBL865930 | 0.85 | MMP2 (0.56) | KMT2AALDH1A1MMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275024-B1 | CARBOXYLIC-ACID DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1991-09-04 | — | — | EP | disclosed |
| US-4833161-A | ANTIDIABETIC AGENTS, ANTICHOLESTEROL AGENTS, ANTILIPEMIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-23 | — | — | US | disclosed |
| EP-0275024-A1 | Carboxylic-acid derivatives, processes for their preparation and medicaments containing these compounds | Roche Diagnostics GmbH (DE) | 1988-07-20 | — | — | EP | disclosed |