SCHEMBL865930

SCHEMBL865930

Cc1ccc(S(=O)(=O)C(CCCCCc2ccc(Cl)cc2)C(=O)O)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 7/20 0.56
MMP9 P14780 6/20 0.56
LMNA P02545 2/20 0.47
HTT P42858 2/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
TSHR P16473 1/20 0.47
CYP2C19 P33261 1/20 0.47
KCNH2 Q12809 1/20 0.47
HIF1A Q16665 1/20 0.47
KMT2A Q03164 3/20 0.47
CNR2 P34972 1/20 0.46
ALDH1A1 P00352 2/20 0.45
RXFP1 Q9HBX9 1/20 0.45
EGFR P00533 1/20 0.44
ERBB2 P04626 1/20 0.44
GAA P10253 2/20 0.44
MMP3 P08254 1/20 0.43
MMP13 P45452 1/20 0.43
MAPT P10636 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10419474 1.00 MMP2 (0.56) MMP2MMP9LMNAHTTCYP2D6
SCHEMBL10420484 1.00 MMP2 (0.56) MMP2MMP9LMNAHTTCYP2D6
SCHEMBL10419952 1.00 MMP2 (0.56) MMP2MMP9LMNAHTTCYP2D6
SCHEMBL10419184 0.99 MMP2 (0.57) MMP2MMP9LMNAHTTCYP2D6
SCHEMBL10419216 0.95 MMP2 (0.59) MMP2MMP9LMNAHTTCYP2D6
SCHEMBL10420790 0.94 MMP2 (0.50) MMP2MMP9KMT2ACNR2ALDH1A1
SCHEMBL10419718 0.94 MMP2 (0.50) MMP2MMP9KMT2ACNR2ALDH1A1
SCHEMBL10419243 0.94 MMP2 (0.50) MMP2MMP9KMT2ACNR2ALDH1A1
SCHEMBL10419942 0.94 MMP2 (0.59) MMP2MMP9ALDH1A1GAAPPARA
SCHEMBL10420376 0.92 MMP2 (0.51) MMP2MMP9CYP2C9CYP2C19KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109715637-B Glucokinase activators and methods of use thereof 百时美施贵宝公司 2022-04-05 CN disclosed
US-10604541-B2 Glucokinase activators and methods of using same BRISTOL-MYERS SQUIBB COMPANY (US) 2020-03-31 US disclosed
US-20190233449-A1 GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME BRISTOL-MYERS SQUIBB COMPANY (US) 2019-08-01 US disclosed
EP-3487862-A1 GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME Bristol-Myers Squibb Company (US) 2019-05-29 EP disclosed
WO-2018017910-A1 GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME BRISTOL-MYERS SQUIBB COMPANY (US) 2018-01-25 WO disclosed
EP-2850073-B1 PYRIMIDINYLPIPERIDINYLOXYPYRIDONE ANALOGUES AS GPR119 MODULATORS BRISTOL MYERS SQUIBB CO (US) 2017-07-19 EP disclosed
US-9174965-B2 Pyrimidinylpiperidinyloxypyridone analogues as GPR119 modulators BRISTOL-MYERS SQUIBB COMPANY (US) 2015-11-03 US disclosed
EP-2566862-B1 BENZOFURANYL ANALOGUES AS GPR119 MODULATORS BRISTOL MYERS SQUIBB CO (US) 2015-09-16 EP disclosed
US-9062028-B2 Bicyclic nitrogen containing heteroaryl TGR5 receptor modulators BRISTOL-MYERS SQUIBB COMPANY (US) 2015-06-23 US disclosed
US-20150133479-A1 PYRIMIDINYLPIPERIDINYLOXYPYRIDONE ANALOGUES AS GPR119 MODULATORS BRISTOL-MYERS SQUIBB COMPANY 2015-05-14 US disclosed
US-20090042919-A1 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY 2009-02-12 US disclosed
US-20090023702-A1 PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS BRISTOL-MYERS SQUIBB COMPANY 2009-01-22 US disclosed
WO-2009012277-A1 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY (US) 2009-01-22 WO disclosed
WO-2009012275-A1 PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2009-01-22 WO disclosed
WO-2008137435-A1 [6,6] AND [6,7]-BICYCLIC GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2008-11-13 WO disclosed
WO-2008137436-A1 [6,5]-BICYCLIC GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2008-11-13 WO disclosed
US-4933367-A Carboxylic acid derivatives, processes for the preparation thereof, the use thereof, and pharmaceutical compositions which contain these compounds BOEHRINGER MANNHEIM GMBH (DE) 1990-06-12 US disclosed
EP-0226636-B1 NEW CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURING PROCESS, USE AND MEDICINES CONTAINING THESE COMPOUNDS Roche Diagnostics GmbH (DE) 1989-02-08 EP disclosed
EP-0226636-A1 NEW CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURING PROCESS, USE AND MEDICINES CONTAINING THESE COMPOUNDS. BOEHRINGER MANNHEIM GMBH (DE) 1987-07-01 EP disclosed
WO-1987000521-A2 NEW CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURING PROCESS, USE AND MEDICINES CONTAINING THESE COMPOUNDS BOEHRINGER MANNHEIM GMBH (DE) 1987-01-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10604541-B2 Glucokinase activators and methods of using same GCK, GCKR, GALK1 MMP2 300/4885MMP9 614/4885LMNA 3749/4885
US-20150133479-A1 PYRIMIDINYLPIPERIDINYLOXYPYRIDONE ANALOGUES AS GPR119 MODULATORS GPR119, GPR180, GPR139 MMP2 4676/4885MMP9 3566/4885LMNA 4490/4885
US-20090042919-A1 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS GPR119, GPR65, GPR84 MMP2 3934/4885MMP9 3749/4885LMNA 4695/4885
US-20190233449-A1 GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME GCK, GCKR, GALK1 MMP2 300/4885MMP9 614/4885LMNA 3749/4885
US-20090023702-A1 PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS GPR119, GPR65, GPR27 MMP2 4524/4885MMP9 4289/4885LMNA 3618/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.