Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 15/20 | 0.72 |
| ▸ | RARB | P10826 | 14/20 | 0.72 |
| ▸ | RARA | P10276 | 11/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | PGR | P06401 | 1/20 | 0.72 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.72 |
| ▸ | GOT1 | P17174 | 1/20 | 0.72 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.72 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077371 | 0.90 | RARB (0.61) | RARGRARBRARAMEN1KMT2A | |
| SCHEMBL8900640 | 0.90 | MEN1 (0.64) | RARGRARBRARAMEN1KMT2A | |
| SCHEMBL8458638 | 0.90 | RARG (0.55) | RARGRARBRARAMEN1KMT2A | |
| Adapalene SCHEMBL29356474 | 0.84 | RARB (1.00) | RARGRARBRARAMEN1KMT2A | |
| Adapalene SCHEMBL2747 | 0.84 | RARB (1.00) | RARGRARBRARAMEN1KMT2A | |
| Adapalene SCHEMBL4302240 | 0.84 | RARB (1.00) | RARGRARBRARAMEN1KMT2A | |
| Adapalene SCHEMBL29393098 | 0.84 | RARB (1.00) | RARGRARBRARAMEN1KMT2A | |
| Adapalene SCHEMBL29357372 | 0.84 | RARB (1.00) | RARGRARBRARAMEN1KMT2A | |
| Adapalene SCHEMBL26688757 | 0.84 | RARB (1.00) | RARGRARBRARAMEN1KMT2A | |
| Adapalene SCHEMBL29688458 | 0.84 | RARB (1.00) | RARGRARBRARAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150098918-A1 | CREAM GELS COMPRISING AT LEAST ONE RETINOID AND BENZOYL PEROXIDE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2015-04-09 | — | — | US | claimed |
| US-20100166852-A1 | Cream gels comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-07-01 | — | — | US | claimed |
| US-20090318550-A1 | Emulsions comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-12-24 | — | — | US | claimed |
| US-10925814-B2 | Cream gels comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2021-02-23 | — | — | US | disclosed |
| US-10702466-B2 | Emulsions comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2020-07-07 | — | — | US | disclosed |
| US-20180263865-A1 | CREAM GELS COMPRISING AT LEAST ONE RETINOID AND BENZOYL PEROXIDE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2018-09-20 | — | — | US | disclosed |
| US-9999577-B2 | Cream gels comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2018-06-19 | — | — | US | disclosed |
| US-20150098918-A1 | CREAM GELS COMPRISING AT LEAST ONE RETINOID AND BENZOYL PEROXIDE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2015-04-09 | — | — | US | disclosed |
| US-8957112-B2 | Cream gels comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2015-02-17 | — | — | US | disclosed |
| US-8557871-B2 | Dermatological compositions comprising retinoids, dispersed benzoyl peroxide and carrageenans | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2013-10-15 | — | — | US | disclosed |
| US-20110003894-A1 | DERMATOLOGICAL COMPOSITIONS COMPRISING RETINOIDS, DISPERSED BENZOYL PEROXIDE AND CARRAGEENANS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-01-06 | — | — | US | disclosed |
| US-20100166852-A1 | Cream gels comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-07-01 | — | — | US | disclosed |
| US-20090318550-A1 | Emulsions comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-12-24 | — | — | US | disclosed |
| US-RE34805-E | Treatment of dermatologic diseases, degeneration of conjunctive tissues; antitumor activity | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1994-12-06 | — | — | US | disclosed |
| US-5212303-A | Benzonaphthalene derivatives, a process for their preparation and their use in therapeutic and cosmetic compositions | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1993-05-18 | — | — | US | disclosed |
| US-5183889-A | For topical or systemic treatment of dermatologic disease, degeneration of conjunction tissues and tumors | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1993-02-02 | — | — | US | disclosed |
| US-4940696-A | Benzonaphthalene derivatives and their use in therapeutic and cosmetic compositions | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIOUES (CIRD) (FR) | 1990-07-10 | — | — | US | disclosed |
| US-4717720-A | DERMATOLOGIC DISEASES, CONJUCTIVE TISSUE DEGENERATION AND ANTI-TUMOR ACTIVITY | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1988-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003894-A1 | DERMATOLOGICAL COMPOSITIONS COMPRISING RETINOIDS, DISPERSED BENZOYL PEROXIDE AND CARRAGEENANS | RARA, RXRA, RARG | RARG 3/4885RARB 5/4885RARA 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.