Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9815415 | 0.87 | HTT (0.51) | HTTKMT2APOLBMEN1LMNA | |
| SCHEMBL12983948 | 0.84 | HTT (0.60) | HTTKMT2APOLBMEN1LMNA | |
| SCHEMBL27524897 | 0.82 | HTT (0.57) | HTTKMT2APOLBMEN1LMNA | |
| SCHEMBL17208836 | 0.81 | BACE1 (0.47) | KMT2APOLBMEN1MAPTALDH1A1 | |
| SCHEMBL18498886 | 0.79 | MAOB (0.40) | KMT2APOLBMEN1LMNASMN1; SMN2 | |
| SCHEMBL2033657 | 0.78 | HTT (0.53) | HTTKMT2APOLBMEN1LMNA | |
| SCHEMBL7086433 | 0.78 | VCAM1 (0.51) | HTTKMT2APOLBMEN1MAPT | |
| SCHEMBL27548058 | 0.78 | CASP6 (0.55) | POLBLMNA | |
| SCHEMBL12089122 | 0.78 | SMN1; SMN2 (0.50) | KMT2AMEN1LMNASMN1; SMN2MAPT | |
| SCHEMBL11526803 | 0.78 | HTT (0.71) | HTTKMT2APOLBMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297607-B1 | GAMMA-L-GLUTAMYL-4-NITROANILIDE DERIVATIVES AND PROCESS FOR DETERMINING GAMMA-GTP ACTIVITY USING THE SAME | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4851572-A | DIAGNOSIS OF LIVER AND BILE DUCT DISORDERS, ALCOHOLISM | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1989-07-25 | — | — | US | disclosed |
| EP-0297607-A1 | Gamma-L-glutamyl-4-nitroanilide derivatives and process for determining gamma-GTP activity using the same | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1989-01-04 | — | — | EP | disclosed |