Biphenyl

Biphenyl

SCHEMBL9816554

O=C(O)/C=C/C(=O)O.c1ccc(-c2ccccc2)cc1.c1ccc(-c2ccccc2)cc1

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol

The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 2/20 0.53
KMT2A known ✓ Q03164 2/20 0.53
ALDH1A1 P00352 5/20 0.63
MAPT P10636 3/20 0.63
KDM4E B2RXH2 2/20 0.63
HCAR2 Q8TDS4 2/20 0.56
HDAC2 Q92769 2/20 0.56
HDAC3 O15379 1/20 0.56
TNKS O95271 1/20 0.56
HDAC4 P56524 1/20 0.56
HDAC1 Q13547 1/20 0.56
HDAC7 Q8WUI4 1/20 0.56
HDAC10 Q969S8 1/20 0.56
HDAC11 Q96DB2 1/20 0.56
HDAC8 Q9BY41 1/20 0.56
TNKS2 Q9H2K2 1/20 0.56
HDAC6 Q9UBN7 1/20 0.56
HDAC9 Q9UKV0 1/20 0.56
HDAC5 Q9UQL6 1/20 0.56
CYP2C9 P11712 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biphenyl SCHEMBL27314777 1.00 ALDH1A1 (0.63) ALDH1A1MAPTKDM4EHCAR2HDAC2
Biphenyl SCHEMBL10898338 1.00 ALDH1A1 (0.63) ALDH1A1MAPTKDM4EHCAR2HDAC2
Biphenyl SCHEMBL5421614 1.00 ALDH1A1 (0.63) ALDH1A1MAPTKDM4EHCAR2HDAC2
Biphenyl SCHEMBL28611778 1.00 ALDH1A1 (0.63) ALDH1A1MAPTKDM4EHCAR2HDAC2
Fumaric Acid SCHEMBL6207261 0.97 ALDH1A1 (0.61) ALDH1A1MAPTKDM4EHCAR2HDAC2
Maleic Acid SCHEMBL6207256 0.97 ALDH1A1 (0.61) ALDH1A1MAPTKDM4EHCAR2HDAC2
Biphenyl SCHEMBL4074902 0.86 ALDH1A1 (0.59) ALDH1A1MAPTKDM4EHCAR2HDAC2
Biphenyl SCHEMBL28534601 0.85 MAPT (0.50) ALDH1A1MAPTKDM4EHCAR2HDAC2
SCHEMBL6947073 0.84 MAPT (0.64) ALDH1A1MAPTKDM4EMEN1KMT2A
SCHEMBL14124718 0.84 MAPT (0.64) ALDH1A1MAPTKDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109705581-B Silicone rubber composition, silicone rubber and preparation method thereof 浙江清华柔性电子技术研究院 2021-07-13 CN claimed
EP-0183552-B2 A PHOTOPOLYMERIZABLE COMPOSITION Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1991-10-16 EP claimed
EP-0183552-B1 A PHOTOPOLYMERIZABLE COMPOSITION Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1988-03-16 EP claimed
EP-0183552-A2 A photopolymerizable composition Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1986-06-04 EP claimed
CN-109705581-B Silicone rubber composition, silicone rubber and preparation method thereof 浙江清华柔性电子技术研究院 2021-07-13 CN disclosed
CN-1028521-C Therapeutic agents BOOTS CO PLC (GB) 1995-05-24 CN disclosed
EP-0183552-B2 A PHOTOPOLYMERIZABLE COMPOSITION Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1991-10-16 EP disclosed
EP-0183552-B1 A PHOTOPOLYMERIZABLE COMPOSITION Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1988-03-16 EP disclosed
EP-0183552-A2 A photopolymerizable composition Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1986-06-04 EP disclosed