Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.47 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.59 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.59 |
| ▸ | GPR52 | Q9Y2T5 | 5/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MMP12 | P39900 | 2/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL4301221 | 0.93 | ALDH1A1 (0.66) | ALDH1A1TAAR1HCAR2GPR52FFAR1 | |
| Biphenyl SCHEMBL5421614 | 0.86 | ALDH1A1 (0.63) | ALDH1A1HCAR2LMNACYP2D6CYP2C19 | |
| Biphenyl SCHEMBL9816554 | 0.86 | ALDH1A1 (0.63) | ALDH1A1HCAR2LMNACYP2D6CYP2C19 | |
| Biphenyl SCHEMBL27314777 | 0.86 | ALDH1A1 (0.63) | ALDH1A1HCAR2LMNACYP2D6CYP2C19 | |
| Biphenyl SCHEMBL10898338 | 0.86 | ALDH1A1 (0.63) | ALDH1A1HCAR2LMNACYP2D6CYP2C19 | |
| Biphenyl SCHEMBL28611778 | 0.86 | ALDH1A1 (0.63) | ALDH1A1HCAR2LMNACYP2D6CYP2C19 | |
| Maleic Acid SCHEMBL6207256 | 0.84 | ALDH1A1 (0.61) | ALDH1A1HCAR2LMNACYP2D6CYP2C19 | |
| Fumaric Acid SCHEMBL6207261 | 0.84 | ALDH1A1 (0.61) | ALDH1A1HCAR2LMNACYP2D6CYP2C19 | |
| Biphenyl SCHEMBL23456981 | 0.81 | ALDH1A1 (0.60) | ALDH1A1TAAR1FFAR1SMN1; SMN2 | |
| Cinnamic Acid SCHEMBL890441 | 0.79 | HCAR2 (0.76) | ALDH1A1HCAR2FFAR1LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791824-B1 | RADICALLY POLYMERIZABLE SULFUR-CONTAINING COMPOUND AND RADICALLY POLYMERIZABLE SULFUR-CONTAINING POLYMER | SHOWA DENKO KK (JP) | 2009-08-05 | — | — | EP | claimed |
| US-20070208149-A1 | Radically Polymerizable Sulfur-Containing Compound And Radically Polymerizable Sulfur-Containing Polymer | SHOWA DENKO K.K. (JP) | 2007-09-06 | — | — | US | claimed |
| EP-1791824-A1 | RADICALLY POLYMERIZABLE SULFUR-CONTAINING COMPOUND AND RADICALLY POLYMERIZABLE SULFUR-CONTAINING POLYMER | Showa Denko K.K. (JP) | 2007-06-06 | — | — | EP | claimed |
| WO-2006033438-A1 | RADICALLY POLYMERIZABLE SULFUR-CONTAINING COMPOUND AND RADICALLY POLYMERIZABLE SULFUR-CONTAINING POLYMER | SHOWA DENKO K.K. (JP) | 2006-03-30 | — | — | WO | claimed |
| EP-1791824-B1 | RADICALLY POLYMERIZABLE SULFUR-CONTAINING COMPOUND AND RADICALLY POLYMERIZABLE SULFUR-CONTAINING POLYMER | SHOWA DENKO KK (JP) | 2009-08-05 | — | — | EP | disclosed |
| US-20090192279-A1 | Radically Polymerizable Sulfur-Containing Compound and Radically Polymerizable Sulfur-Containing Polymer | SHOWA DENKO K.K. (JP) | 2009-07-30 | — | — | US | disclosed |
| US-7518001-B2 | Radically polymerizable sulfur-containing compound and radically polymerizable sulfur-containing polymer | SHOWA DENKO K.K. (JP) | 2009-04-14 | — | — | US | disclosed |
| US-20070208149-A1 | Radically Polymerizable Sulfur-Containing Compound And Radically Polymerizable Sulfur-Containing Polymer | SHOWA DENKO K.K. (JP) | 2007-09-06 | — | — | US | disclosed |
| EP-1791824-A1 | RADICALLY POLYMERIZABLE SULFUR-CONTAINING COMPOUND AND RADICALLY POLYMERIZABLE SULFUR-CONTAINING POLYMER | Showa Denko K.K. (JP) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006033438-A1 | RADICALLY POLYMERIZABLE SULFUR-CONTAINING COMPOUND AND RADICALLY POLYMERIZABLE SULFUR-CONTAINING POLYMER | SHOWA DENKO K.K. (JP) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208149-A1 | Radically Polymerizable Sulfur-Containing Compound And Radically Polymerizable Sulfur-Containing Polymer | CBS, TST, MSRB3 | ADRA1A 4177/4885SLC6A3 3684/4885ALDH1A1 1005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.