Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ACR | P10323 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SCD | O00767 | 1/20 | 0.48 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9133800 | 0.89 | ACR (0.51) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL9136302 | 0.87 | ACR (0.50) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL9817266 | 0.87 | ACR (0.50) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL9134159 | 0.85 | NPC1 (0.50) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL9132730 | 0.83 | NPC1 (0.48) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL9510816 | 0.82 | MAPT (0.63) | SMN1; SMN2NPC1RAB9AMAPTACR | |
| SCHEMBL9137610 | 0.78 | MEN1 (0.60) | NPC1RAB9AMAPK1POLB | |
| SCHEMBL25534280 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL14069154 | 0.75 | THRB (0.56) | SMN1; SMN2NPC1RAB9AMAPTTHRB | |
| SCHEMBL21939043 | 0.75 | THRB (0.56) | SMN1; SMN2NPC1RAB9AMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5059614-A | NOVEL ISOXAZOLE AND ISOXAZOLINE COMPOUNDS WITH ANTICONVULSANT ACTIVITY PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITION CONTAINING THEM | NOVAPHARME (FR) | 1991-10-22 | — | — | US | disclosed |