Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 8/20 | 0.45 |
| ▸ | RARG | P13631 | 8/20 | 0.45 |
| ▸ | RARA | P10276 | 7/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | IRS1 | P35568 | 1/20 | 0.32 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 2/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9817852 | 0.99 | RARB (0.45) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL9817700 | 0.97 | RARB (0.46) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL9817691 | 0.94 | RARA (0.47) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL9817660 | 0.91 | RARA (0.49) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL8676360 | 0.90 | FDFT1 (0.36) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL9817738 | 0.88 | RARB (0.55) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL9817713 | 0.87 | RARA (0.49) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL9817794 | 0.84 | RARB (0.44) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL9817637 | 0.83 | RXRA (0.37) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL9817775 | 0.83 | RARB (0.43) | RARBRARGRARACYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290130-B1 | ACETYLENES DISUBSTITUTED WITH A PHENYL GROUP AND A HETEROBICYCLIC GROUP HAVING RETINOID LIKE ACTIVITY | ALLERGAN, INC (US) | 1991-11-06 | — | — | EP | disclosed |
| US-4810804-A | PSORIASIS | ALLERGAN, INC. (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0290130-A1 | Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid like activity | ALLERGAN, INC (US) | 1988-11-09 | — | — | EP | disclosed |