Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3429238 | 0.84 | MAPT (0.57) | LMNAPOLBMAPTALDH1A1RAB9A | |
| SCHEMBL2112338 | 0.80 | NPC1 (0.56) | LMNAPOLBMAPTKMT2AALDH1A1 | |
| SCHEMBL2112336 | 0.80 | NPC1 (0.56) | LMNAPOLBMAPTKMT2AALDH1A1 | |
| SCHEMBL8052548 | 0.77 | LMNA (0.48) | LMNANAPRTHSD17B10POLBMAPT | |
| SCHEMBL1522066 | 0.77 | NAPRT (0.52) | LMNANAPRTHSD17B10POLBMAPT | |
| SCHEMBL10690558 | 0.75 | NAPRT (0.46) | LMNANAPRTHSD17B10POLBMAPT | |
| SCHEMBL10687685 | 0.75 | APEX1 (0.55) | LMNAMAPTKMT2AMEN1GAA | |
| SCHEMBL14817483 | 0.74 | NAPRT (0.53) | LMNANAPRTHSD17B10POLBMAPT | |
| SCHEMBL22110225 | 0.74 | FAAH (0.50) | LMNANAPRTHSD17B10POLBMAPT | |
| SCHEMBL10272322 | 0.73 | CETP (0.54) | LMNANAPRTHSD17B10POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0253503-B1 | SUBSTITUTED ANILIDES HAVING ANTIANDROGENIC PROPERTIES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-12-11 | — | — | EP | disclosed |
| EP-0100172-B1 | AMIDE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-08-12 | — | — | EP | disclosed |
| US-4636505-A | ANTIANDROGENS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-01-13 | — | — | US | disclosed |
| EP-0100172-A1 | Amide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-02-08 | — | — | EP | disclosed |