Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 17/20 | 0.47 |
| ▸ | CA2 | P00918 | 17/20 | 0.47 |
| ▸ | CA4 | P22748 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 10/20 | 0.42 |
| ▸ | CA9 | Q16790 | 10/20 | 0.42 |
| ▸ | CA6 | P23280 | 2/20 | 0.42 |
| ▸ | CA5A | P35218 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1037129 | 0.70 | CA2 (0.50) | CA1CA2CA4CA12CA9 | |
| SCHEMBL10867332 | 0.69 | CA1 (0.42) | CA1CA2CA4CA12CA9 | |
| SCHEMBL31525869 | 0.69 | S1PR1 (0.42) | CA1CA2CA12CA9ACLY | |
| SCHEMBL21046778 | 0.68 | ACLY (0.50) | CA1CA2CA12CA9ACLY | |
| Hydrochloric Acid SCHEMBL28293567 | 0.66 | ACLY (0.48) | CA1CA2CA12CA9ACLY | |
| SCHEMBL5806005 | 0.63 | CA2 (0.34) | CA1CA2CA4CA12CA9 | |
| SCHEMBL20858621 | 0.62 | CYP2A6 (0.38) | TDP1 | |
| SCHEMBL6038911 | 0.62 | CA1 (0.48) | CA1CA2CA4CA12CA9 | |
| SCHEMBL18876021 | 0.62 | TRPA1 (0.32) | ACLY | |
| SCHEMBL29120024 | 0.62 | TET2 (0.40) | CA1CA2CA4CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0173899-B1 | 2,3-DIHYDROBENZOFURAN-5-SULFONAMIDE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 1991-12-18 | — | — | EP | disclosed |
| US-4659709-A | LESS ADVERSE SIDE-EFFECTS | SHIONOGI & CO. (JP) | 1987-04-21 | — | — | US | disclosed |
| EP-0173899-A2 | 2,3-Dihydrobenzofuran-5-sulfonamide derivatives | SHIONOGI & CO., LTD. (JP) | 1986-03-12 | — | — | EP | disclosed |