Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95837 | 0.83 | CYP2C19 (0.35) | HTTCYP2C19CYP2C9ALDH1A1CYP3A4 | |
| SCHEMBL10079991 | 0.80 | HTT (0.40) | HTTCYP2C19CYP2C9ALDH1A1CYP3A4 | |
| SCHEMBL954426 | 0.78 | HTT (0.39) | HTTCYP2C19CYP2C9ALDH1A1CYP3A4 | |
| SCHEMBL1044900 | 0.77 | HTT (0.47) | HTTCYP2C19CYP2C9ALDH1A1CYP3A4 | |
| SCHEMBL910441 | 0.76 | ESR1 (0.46) | ALDH1A1GABRA1GABRB2LMNAGAA | |
| SCHEMBL9165861 | 0.76 | ESR1 (0.46) | ALDH1A1GABRA1GABRB2LMNAGAA | |
| SCHEMBL11791692 | 0.74 | IDO1 (0.36) | HTTCYP2C19CYP2C9ALDH1A1HSD11B1 | |
| SCHEMBL2675708 | 0.74 | CYP3A4 (0.38) | CYP2C9ALDH1A1CYP3A4ALOX15MAOA | |
| SCHEMBL911040 | 0.74 | GABRA1 (0.58) | HTTALDH1A1CYP3A4ALOX15GABRA1 | |
| SCHEMBL6141021 | 0.74 | CYP3A4 (0.40) | CYP2C9ALDH1A1CYP3A4HSD11B1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126635-B1 | NOVEL OXINDOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-18 | — | — | EP | disclosed |
| US-4694017-A | 2-amido 3(oxindol-3-yl)propionic acids having antiulcer activity | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-09-15 | — | — | US | disclosed |
| EP-0126635-A2 | Novel oxindole derivative | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-11-28 | — | — | EP | disclosed |