Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | PTPRC | P08575 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1888537 | 0.78 | CYP3A4 (0.38) | CYP3A4ALOX15CASP1CASP7SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27897741 | 0.77 | CYP3A4 (0.38) | CYP3A4ALOX15CASP1CASP7SMN1; SMN2 | |
| SCHEMBL910441 | 0.76 | ESR1 (0.46) | ALDH1A1GABRA1GABRB2ADRA2BGAA | |
| SCHEMBL9165861 | 0.76 | ESR1 (0.46) | ALDH1A1GABRA1GABRB2ADRA2BGAA | |
| SCHEMBL11503347 | 0.75 | CYP3A4 (0.35) | CYP3A4ALOX15CASP1CASP7SMN1; SMN2 | |
| SCHEMBL9818280 | 0.74 | HTT (0.42) | CYP3A4ALOX15ALDH1A1CA1CA2 | |
| SCHEMBL911040 | 0.74 | GABRA1 (0.58) | CYP3A4ALOX15SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL6141021 | 0.74 | CYP3A4 (0.40) | CYP3A4ALDH1A1GAACYP2C9 | |
| SCHEMBL6141168 | 0.74 | ADRB2 (0.42) | CYP3A4TDP1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL16512108 | 0.74 | CYP3A4 (0.48) | CYP3A4ALOX15CASP1CASP7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173128-B2 | Methods and compositions for inducing apoptosis in cancer cells with an anti-DR5 antibody | IRM LLC (BM) | 2012-05-08 | — | — | US | disclosed |
| EP-1576179-B1 | METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER CELLS | IRM LLC (BM) | 2010-09-15 | — | — | EP | disclosed |
| WO-2008154439-A1 | METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER CELLS | IRM LLC (BM) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008066854-A2 | METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER CELLS | NOVARTIS AG (CH) | 2008-06-05 | — | — | WO | disclosed |
| US-7229617-B2 | Methods and compositions for inducing apoptosis in cancer cells | IRM LLC (BM) | 2007-06-12 | — | — | US | disclosed |
| US-20070128204-A1 | Methods and compositions for inducing apoptosis in cancer cells | IRM LLC (BM) | 2007-06-07 | — | — | US | disclosed |
| EP-1576179-A4 | METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER CELLS | IRM LLC (BM) | 2007-06-06 | — | — | EP | disclosed |
| EP-1656390-A2 | COMPOSITIONS OF LIPOPEPTIDE ANTIBIOTIC DERIVATIVES AND METHODS OF USE THEREOF | MIGENIX INC. (CA) | 2006-05-17 | — | — | EP | disclosed |
| EP-1576179-A2 | METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER CELLS | IRM LLC (BM) | 2005-09-21 | — | — | EP | disclosed |
| US-20050079172-A1 | Methods and compositions for inducing apoptosis in cancer cells | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2005-04-14 | — | — | US | disclosed |
| WO-2004050895-A2 | METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER CELLS | IRM LLC (BM) | 2004-06-17 | — | — | WO | disclosed |
| US-20040005562-A9 | Comprises tranferase protein associated with biosynthesis of taxoids for treating breast and ovarian cancers | WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION | 2004-01-08 | — | — | US | disclosed |
| US-20030108891-A1 | Transacylases of the paclitaxel biosynthetic pathway | WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION | 2003-06-12 | — | — | US | disclosed |
| EP-1178784-A1 | NEW PHARMACEUTICAL COMBINATIONS FOR NOS INHIBITORS | Pfizer Products Inc. (US) | 2002-02-13 | — | — | EP | disclosed |
| EP-1173413-A1 | USE OF 2,4-DIAMINO-3-HYDROXYCARBOXYLIC ACID DERIVATIVES AS PROTEASOME INHIBITORS | Novartis AG (CH) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000071107-A2 | NEW PHARMACEUTICAL COMBINATIONS FOR NOS INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-11-30 | — | — | WO | disclosed |
| WO-2000064863-A1 | USE OF 2,4-DIAMINO-3-HYDROXYCARBOXYLIC ACID DERIVATIVES AS PROTEASOME INHIBITORS | NOVARTIS AG (CH) | 2000-11-02 | — | — | WO | disclosed |
| US-4310551-A | Pharmacologically active substituted 1,2,4-triazines | DIAMOND SHAMROCK CORPORATION (US) | 1982-01-12 | — | — | US | disclosed |
| US-4251527-A | ANTIINFLAMMATORY AGENTS | DIAMOND SHAMROCK CORPORATION (US) | 1981-02-17 | — | — | US | disclosed |
| US-4157392-A | HYPOTENSIVE AGENTS, ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS AND NERVOUS SYSTEM EFFECTS | DIAMOND SHAMROCK CORPORATION (US) | 1979-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050079172-A1 | Methods and compositions for inducing apoptosis in cancer cells | BAD, BAX, CASP3 | CYP3A4 3056/4885ALOX15 476/4885CASP1 66/4885 |
| US-20070128204-A1 | Methods and compositions for inducing apoptosis in cancer cells | BAD, BAX, BID | CYP3A4 4496/4885ALOX15 766/4885CASP1 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.