Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 4/20 | 0.38 |
| ▸ | PPARD | Q03181 | 4/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9818762 | 1.00 | HTT (0.42) | HTTALDH1A1HPGDAKR1B1PPARG | |
| SCHEMBL9819041 | 0.89 | HTT (0.40) | HTTALDH1A1HPGDAKR1B1PPARG | |
| SCHEMBL9819039 | 0.89 | HTT (0.40) | HTTALDH1A1HPGDAKR1B1PPARG | |
| SCHEMBL9818872 | 0.85 | ABCB1 (0.46) | HTTHPGDAKR1B1MTNR1AMTNR1B | |
| SCHEMBL9818878 | 0.85 | ABCB1 (0.46) | HTTHPGDAKR1B1MTNR1AMTNR1B | |
| SCHEMBL9819040 | 0.82 | LTB4R (0.43) | HTTALDH1A1HPGDPPARGPPARD | |
| SCHEMBL9819044 | 0.82 | LTB4R (0.43) | HTTALDH1A1HPGDPPARGPPARD | |
| SCHEMBL9818765 | 0.80 | AKR1B1 (0.45) | HTTALDH1A1AKR1B1PPARGPPARD | |
| SCHEMBL9818767 | 0.80 | AKR1B1 (0.45) | HTTALDH1A1AKR1B1PPARGPPARD | |
| SCHEMBL10650423 | 0.80 | HTR2C (0.40) | HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |