Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 3/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9818808 | 0.81 | CYP2D6 (0.53) | CYP2D6MC4RKCNH2CHRM2ADRA2A | |
| SCHEMBL9870097 | 0.80 | SRD5A2 (0.36) | CYP2D6ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL6255523 | 0.79 | MEN1 (0.56) | CYP2D6KCNH2CHRM2CHRM1SLC6A3 | |
| SCHEMBL1586528 | 0.78 | CYP2D6 (0.70) | CYP2D6HSD11B1MC4RCHRM2CHRM1 | |
| SCHEMBL4601165 | 0.78 | CYP2D6 (0.70) | CYP2D6HSD11B1MC4RCHRM2CHRM1 | |
| SCHEMBL8099850 | 0.78 | CYP2D6 (0.70) | CYP2D6HSD11B1MC4RCHRM2CHRM1 | |
| SCHEMBL19613500 | 0.78 | CYP2D6 (0.70) | CYP2D6HSD11B1MC4RCHRM2CHRM1 | |
| SCHEMBL9819007 | 0.74 | CTDSP1 (0.43) | CHRM2CHRM1SLC6A3SLC6A2ALDH1A1 | |
| SCHEMBL9818874 | 0.74 | CHRM2 (0.44) | CYP2D6KCNH2CHRM2ADRA2ACHRM1 | |
| SCHEMBL28041845 | 0.73 | CYP2D6 (0.40) | CYP2D6HSD11B1MC4RKCNH2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259227-B1 | BENZHYDRYLOXYETHYL PIPERIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Société anonyme: LES LABORATOIRES MERAM (FR) | 1991-12-27 | — | — | EP | disclosed |
| US-4983614-A | ANTISPASMODIC, ANTIALLERGENIC AND ANTIHISTAMINE AGENTS | LES LABORATOIRES MERAM (FR) | 1991-01-08 | — | — | US | disclosed |
| EP-0259227-A1 | Benzhydryloxyethyl piperidine derivatives, process for their preparation and pharmaceutical compositions containing them | Société anonyme: LES LABORATOIRES MERAM (FR) | 1988-03-09 | — | — | EP | disclosed |