Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1913887 | 0.83 | CACNA2D1 (0.45) | PPARGPPARAHPGDMEN1KMT2A | |
| SCHEMBL6227633 | 0.83 | CACNA2D1 (0.45) | PPARGPPARAHPGDMEN1KMT2A | |
| SCHEMBL1418060 | 0.83 | MTNR1A (0.59) | HPGDMEN1KMT2AFFAR1MTNR1A | |
| SCHEMBL31053102 | 0.82 | MTNR1B (0.61) | FFAR1MTNR1AMTNR1B | |
| SCHEMBL7174245 | 0.82 | PPARG (0.48) | PPARGPPARAHPGDMEN1KMT2A | |
| SCHEMBL2108300 | 0.81 | ALDH1A1 (0.50) | PPARGPPARAHPGDKMT2AFFAR1 | |
| SCHEMBL2108302 | 0.81 | ALDH1A1 (0.50) | PPARGPPARAHPGDKMT2AFFAR1 | |
| SCHEMBL6721786 | 0.81 | HSD17B10 (0.51) | KMT2AMTNR1AMTNR1BMRGPRX4 | |
| SCHEMBL9818994 | 0.80 | PPARG (0.56) | PPARGPPARAMRGPRX4NR4A2 | |
| SCHEMBL3579103 | 0.80 | MTNR1A (0.57) | PPARGPPARAHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1015545-B | preparation method of glycolic acid derivative for treating diabetic complications | PFIZER (US) | 1992-02-19 | — | — | CN | disclosed |
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| CN-87100191-A | The hydroxy acid derivative of treatment diabetic complication | — | 1987-09-09 | — | — | CN | disclosed |
| WO-1987004344-A1 | HYDROXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |