Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | GRM8 | O00222 | 2/20 | 0.36 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9818841 | 1.00 | POLB (0.42) | POLBAKR1B1MAOBALDH1A1BRD4 | |
| SCHEMBL7976360 | 0.80 | CYP2C9 (0.39) | POLBALDH1A1GRM8GRM7GRM4 | |
| SCHEMBL27865204 | 0.80 | HTT (0.39) | ALDH1A1GRM8GRM7GRM4GRM2 | |
| SCHEMBL9535853 | 0.78 | AKR1B1 (0.46) | AKR1B1MAOBTDP1 | |
| SCHEMBL27852235 | 0.78 | ALDH1A1 (0.36) | POLBALDH1A1GRM8GRM7GRM4 | |
| SCHEMBL9818767 | 0.76 | AKR1B1 (0.45) | POLBAKR1B1ALDH1A1MEN1KMT2A | |
| SCHEMBL31110943 | 0.76 | PARP1 (0.36) | POLBAKR1B1ALDH1A1BRD4TDP1 | |
| SCHEMBL9818765 | 0.76 | AKR1B1 (0.45) | POLBAKR1B1ALDH1A1MEN1KMT2A | |
| SCHEMBL4291278 | 0.76 | SGMS2 (0.37) | POLBALDH1A1GRM8GRM7GRM4 | |
| SCHEMBL27581217 | 0.76 | ALDH1A1 (0.35) | POLBALDH1A1GRM8GRM7GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |