Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.44 |
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9818896 | 0.81 | PBRM1 (0.56) | SIGMAR1HTR1AABCB1ARCYP19A1 | |
| SCHEMBL9819034 | 0.81 | SIGMAR1 (0.49) | SIGMAR1HTR1AABCB1ARCYP19A1 | |
| SCHEMBL1979508 | 0.81 | PBRM1 (0.56) | SIGMAR1HTR1AABCB1ARCYP19A1 | |
| SCHEMBL11377847 | 0.80 | SIGMAR1 (0.66) | SIGMAR1HTR1AABCB1ARCYP19A1 | |
| SCHEMBL7269358 | 0.74 | PBRM1 (0.61) | ABCB1ARCYP19A1ABCG2RORC | |
| SCHEMBL9818700 | 0.74 | SIGMAR1 (0.43) | SIGMAR1HTR1AABCB1ARABCG2 | |
| SCHEMBL8131503 | 0.71 | RORC (0.39) | ABCB1ARCYP19A1ABCG2RORC | |
| SCHEMBL10487800 | 0.69 | AKR1B1 (0.58) | — | |
| SCHEMBL9431969 | 0.68 | SIRT2 (0.53) | SIGMAR1HTR1AABCB1ARCYP19A1 | |
| SCHEMBL9818840 | 0.68 | MAOB (0.42) | SIGMAR1HTR1AABCB1ARMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| WO-1987004344-A1 | HYDROXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |