Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20472411 | 0.92 | ROCK2 (0.46) | ROCK2CYP3A4ALDH1A1POLBNPC1 | |
| SCHEMBL20472413 | 0.90 | MLYCD (0.43) | ROCK2CYP3A4ALDH1A1POLBNPC1 | |
| SCHEMBL9819347 | 0.80 | MLYCD (0.44) | ROCK2FFAR1 | |
| SCHEMBL11879990 | 0.79 | CYP3A4 (0.42) | ROCK2CYP3A4ALDH1A1POLBNPC1 | |
| SCHEMBL20472409 | 0.77 | ROCK2 (0.41) | ROCK2ALDH1A1MAPTSMN1; SMN2FFAR1 | |
| SCHEMBL657249 | 0.76 | CNR2 (0.56) | CYP3A4ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL11217740 | 0.73 | PTGIR (0.53) | SMN1; SMN2 | |
| SCHEMBL1114715 | 0.72 | CYP3A4 (0.53) | CYP3A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL11179335 | 0.72 | CYP3A4 (0.49) | CYP3A4ALDH1A1POLBMAPTMMP2 | |
| SCHEMBL5049977 | 0.72 | ROCK2 (0.51) | ROCK2ALDH1A1POLBNPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162669-B1 | ANTICONVULSIVE COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-11 | — | — | EP | disclosed |
| US-4588729-A | Treating convulsions with dihydrouracil derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1986-05-13 | — | — | US | disclosed |
| EP-0162669-A2 | Anticonvulsive compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-11-27 | — | — | EP | disclosed |