Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819287 | 0.84 | MAPT (0.61) | MAPTMEN1KMT2APOLBGAA | |
| SCHEMBL20540420 | 0.80 | MEN1 (0.61) | MAPTMEN1KMT2APOLBEPHX1 | |
| SCHEMBL1608851 | 0.77 | POLB (0.72) | MAPTMEN1KMT2APOLBGAA | |
| SCHEMBL1514673 | 0.74 | EPHX1 (0.57) | MAPTMEN1KMT2APOLBEPHX1 | |
| SCHEMBL21820774 | 0.72 | ALDH1A1 (0.59) | MAPTPOLBGAAL3MBTL1LMNA | |
| SCHEMBL11554796 | 0.72 | MEN1 (0.51) | MAPTMEN1KMT2APOLBEPHX1 | |
| SCHEMBL1092575 | 0.72 | MEN1 (0.69) | MAPTMEN1KMT2APOLBEPHX1 | |
| SCHEMBL20472451 | 0.72 | APEX1 (0.60) | KMT2AEPHX1GAAL3MBTL1LMNA | |
| SCHEMBL11793898 | 0.72 | TDP1 (0.66) | MAPTMEN1KMT2APOLBEPHX1 | |
| SCHEMBL11136449 | 0.71 | MAPT (0.71) | MAPTMEN1KMT2APOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162669-B1 | ANTICONVULSIVE COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-11 | — | — | EP | disclosed |
| US-4588729-A | Treating convulsions with dihydrouracil derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1986-05-13 | — | — | US | disclosed |
| EP-0162669-A2 | Anticonvulsive compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-11-27 | — | — | EP | disclosed |