Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690575 | 0.86 | ALDH1A1 (0.58) | TSHRALDH1A1TDP1HPGDSIGMAR1 | |
| SCHEMBL10977025 | 0.83 | TSHR (0.51) | TSHRGPR35ALDH1A1TDP1HPGD | |
| SCHEMBL1167739 | 0.82 | TSHR (0.53) | TSHRGPR35ALDH1A1TDP1HPGD | |
| SCHEMBL94768 | 0.81 | TSHR (0.52) | TSHRGPR35ALDH1A1TDP1HPGD | |
| SCHEMBL9429301 | 0.81 | ALDH1A1 (0.56) | TSHRALDH1A1HPGDSIGMAR1SMN1; SMN2 | |
| SCHEMBL27868260 | 0.81 | SIGMAR1 (0.55) | TSHRGPR35ALDH1A1SIGMAR1 | |
| SCHEMBL14845129 | 0.81 | GPR35 (0.49) | TSHRGPR35ALDH1A1TDP1HPGD | |
| SCHEMBL22614890 | 0.80 | GPR35 (0.47) | TSHRGPR35ALDH1A1TDP1HPGD | |
| SCHEMBL94769 | 0.79 | GPR35 (0.55) | TSHRGPR35ALDH1A1TDP1HPGD | |
| SCHEMBL9641198 | 0.79 | TSHR (0.55) | TSHRGPR35ALDH1A1TDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4987132-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-01-22 | — | — | US | disclosed |
| CN-1030415-A | Saturated heterocycle carboxamide derivatives and its preparation method | YAMANOUCHI PHARMA CO LTD (JP) | 1989-01-18 | — | — | CN | disclosed |
| EP-0279681-A2 | Saturated heterocyclic carboxamide derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-08-24 | — | — | EP | disclosed |