Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28689035 | 0.91 | CTSK (0.46) | SIGMAR1KCNH2ADRA1ASLC6A3SMN1; SMN2 | |
| SCHEMBL7279393 | 0.90 | ACE (0.45) | SIGMAR1KCNH2HDAC3MAPK1ADRA1A | |
| SCHEMBL1828574 | 0.89 | SMN1; SMN2 (0.52) | SIGMAR1KCNH2ADRA1ASLC6A3SMN1; SMN2 | |
| SCHEMBL7266310 | 0.87 | ACE (0.47) | SIGMAR1KCNH2MAPK1SMN1; SMN2 | |
| SCHEMBL8895432 | 0.80 | GRIK1 (0.50) | SIGMAR1KCNH2GRIK1MAOA | |
| SCHEMBL8896138 | 0.80 | GRIK1 (0.50) | SIGMAR1KCNH2GRIK1MAOA | |
| SCHEMBL585515 | 0.80 | SIGMAR1 (0.45) | SIGMAR1KCNH2SMN1; SMN2GRIK1 | |
| SCHEMBL13629461 | 0.80 | GRIK1 (0.50) | SIGMAR1KCNH2GRIK1MAOA | |
| SCHEMBL12249323 | 0.78 | ACE (0.51) | MAPK1SLC6A3SMN1; SMN2 | |
| SCHEMBL7266830 | 0.78 | ACE (0.51) | MAPK1SLC6A3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047399-A | Hypotensive Agents | SCHERING CORPORATION (US) | 1991-09-10 | — | — | US | disclosed |