Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.55 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.55 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.55 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359213 | 0.86 | GRIN2D (0.57) | ADRA1AGRIN2DGRIN3BADRA1DADRA1B | |
| SCHEMBL358258 | 0.86 | GRIN2D (0.57) | ADRA1AGRIN2DGRIN3BADRA1DADRA1B | |
| SCHEMBL11159052 | 0.84 | GRIN2D (0.56) | ADRA1AGRIN2DGRIN3BADRA1DADRA1B | |
| SCHEMBL11166093 | 0.81 | SIGMAR1 (0.56) | ADRA1AGRIN2DGRIN3BADRA1DADRA1B | |
| SCHEMBL7510260 | 0.81 | ADRA1A (0.53) | ADRA1AGRIN2DGRIN3BADRA1DADRA1B | |
| SCHEMBL8488319 | 0.81 | GRIN2D (0.53) | ADRA1AGRIN2DGRIN3BADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL10901527 | 0.80 | SIGMAR1 (0.54) | ADRA1AGRIN2DGRIN3BADRA1DADRA1B | |
| SCHEMBL11459450 | 0.79 | LTA4H (0.61) | ADRA1AGRIN2DGRIN3BADRA1DADRA1B | |
| SCHEMBL8597686 | 0.78 | GRIN2D (0.85) | ADRA1AGRIN2DGRIN3BADRA1DADRA1B | |
| SCHEMBL3637933 | 0.76 | KDM4E (0.39) | ADRA1AGRIN2DGRIN3BADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5017724-A | Antihypoxic, CNS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-21 | — | — | US | disclosed |
| EP-0267024-B1 | HYDROFLUORENE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | EP | disclosed |
| EP-0267024-A2 | Hydrofluorene derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-11 | — | — | EP | disclosed |