Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9442022 | 0.95 | SIGMAR1 (0.60) | SIGMAR1LTA4HSLC6A3GRIN2BHRH3 | |
| SCHEMBL4054826 | 0.89 | SLC6A3 (0.58) | SIGMAR1LTA4HSLC6A3MAOAHRH3 | |
| SCHEMBL688048 | 0.78 | SIGMAR1 (0.48) | SIGMAR1SLC6A3POLBHRH3 | |
| SCHEMBL5302082 | 0.76 | LTA4H (0.86) | SIGMAR1LTA4HSLC6A3POLBGRIN2B | |
| SCHEMBL83687 | 0.74 | SIGMAR1 (0.86) | SIGMAR1LTA4HSLC6A3POLBGRIN2B | |
| SCHEMBL20382580 | 0.73 | LTA4H (0.86) | SIGMAR1LTA4HSLC6A3POLBGRIN2B | |
| Ammonia Solution, Strong SCHEMBL28704893 | 0.73 | SIGMAR1 (0.83) | SIGMAR1LTA4HSLC6A3POLBGRIN2B | |
| Hydrochloric Acid SCHEMBL7239522 | 0.73 | LTA4H (0.80) | SIGMAR1LTA4HSLC6A3POLBGRIN2B | |
| Hydrochloric Acid SCHEMBL8037018 | 0.73 | SIGMAR1 (0.83) | SIGMAR1LTA4HSLC6A3POLBGRIN2B | |
| SCHEMBL1514871 | 0.72 | SIGMAR1 (0.50) | SIGMAR1SLC6A3POLBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5017724-A | Antihypoxic, CNS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-21 | — | — | US | disclosed |
| EP-0267024-B1 | HYDROFLUORENE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | EP | disclosed |
| EP-0267024-A2 | Hydrofluorene derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-11 | — | — | EP | disclosed |