Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | RAD52 | P43351 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 6/20 | 0.44 |
| ▸ | BCHE | P06276 | 4/20 | 0.44 |
| ▸ | ACHE | P22303 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9821182 | 0.87 | KMT2A (0.59) | KMT2ARAD52POLBKDM4EALDH1A1 | |
| SCHEMBL9821025 | 0.75 | HSD17B10 (0.51) | KMT2ARAD52POLBKDM4EALDH1A1 | |
| SCHEMBL6652586 | 0.75 | KMT2A (0.60) | KMT2ARAD52POLBKDM4EALDH1A1 | |
| SCHEMBL9821131 | 0.74 | KMT2A (0.59) | KMT2ARAD52POLBKDM4EALDH1A1 | |
| SCHEMBL1868598 | 0.74 | RAD52 (1.00) | KMT2ARAD52POLBKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9821072 | 0.73 | KMT2A (0.57) | KMT2ARAD52POLBKDM4EALDH1A1 | |
| SCHEMBL6653650 | 0.72 | KMT2A (0.54) | KMT2ARAD52POLBKDM4EALDH1A1 | |
| SCHEMBL7646678 | 0.72 | KMT2A (0.61) | KMT2ARAD52POLBKDM4EALDH1A1 | |
| SCHEMBL6652588 | 0.72 | POLB (0.56) | KMT2ARAD52POLBKDM4EALDH1A1 | |
| SCHEMBL7653573 | 0.68 | APP (0.52) | KMT2ARAD52POLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4789678-A | Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-12-06 | — | — | US | claimed |
| EP-0258755-B1 | ALPHA-ALKYL-4-AMINO-3-QUINOLINE-METHANOLS AND 1-(4-ARALKYLAMINO-3-QUINOLINYL) ALKANONES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4840972-A | Relief from memory dysfunction with α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-06-20 | — | — | US | disclosed |
| US-4789678-A | Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-12-06 | — | — | US | disclosed |
| EP-0258755-A1 | Alpha-alkyl-4-amino-3-quinoline-methanols and 1-(4-aralkylamino-3-quinolinyl) alkanones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-03-09 | — | — | EP | disclosed |