Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9821028 | 0.83 | HSD17B10 (0.55) | HSD17B10TP53ALDH1A1HPGDCYP1A2 | |
| SCHEMBL9821010 | 0.75 | KMT2A (0.56) | ALDH1A1HPGDCYP1A2SMN1; SMN2KDM4E | |
| SCHEMBL27296318 | 0.73 | ALDH1A1 (0.64) | HSD17B10TP53ALDH1A1HPGDCYP1A2 | |
| SCHEMBL30025532 | 0.73 | ALDH1A1 (0.64) | HSD17B10TP53ALDH1A1HPGDCYP1A2 | |
| SCHEMBL440157 | 0.73 | ALDH1A1 (0.64) | HSD17B10TP53ALDH1A1HPGDCYP1A2 | |
| SCHEMBL27374101 | 0.72 | HSD17B10 (0.62) | HSD17B10TP53ALDH1A1HPGDCYP1A2 | |
| SCHEMBL6530612 | 0.70 | HSD17B10 (0.56) | HSD17B10TP53ALDH1A1HPGDCYP1A2 | |
| SCHEMBL12877163 | 0.70 | GPR3 (0.43) | HSD17B10TP53ALDH1A1HPGDCYP1A2 | |
| SCHEMBL9820858 | 0.70 | HSD17B10 (0.72) | HSD17B10TP53ALDH1A1HPGDCYP1A2 | |
| SCHEMBL12877165 | 0.70 | MAOA (0.46) | HSD17B10TP53ALDH1A1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0258755-B1 | ALPHA-ALKYL-4-AMINO-3-QUINOLINE-METHANOLS AND 1-(4-ARALKYLAMINO-3-QUINOLINYL) ALKANONES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-09-11 | — | — | EP | claimed |
| US-4789678-A | Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-12-06 | — | — | US | claimed |
| EP-0258755-A1 | Alpha-alkyl-4-amino-3-quinoline-methanols and 1-(4-aralkylamino-3-quinolinyl) alkanones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-03-09 | — | — | EP | claimed |
| EP-0258755-B1 | ALPHA-ALKYL-4-AMINO-3-QUINOLINE-METHANOLS AND 1-(4-ARALKYLAMINO-3-QUINOLINYL) ALKANONES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4840972-A | Relief from memory dysfunction with α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-06-20 | — | — | US | disclosed |
| US-4789678-A | Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-12-06 | — | — | US | disclosed |