Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563428 | 0.73 | DDB1 (0.51) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23745244 | 0.73 | DDB1 (0.51) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20342557 | 0.69 | HDAC4 (0.48) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14938938 | 0.67 | NPC1 (0.62) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14467140 | 0.67 | TDP1 (0.40) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL14466510 | 0.67 | KDM4E (0.43) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL395878 | 0.66 | TDP1 (0.66) | MAPTKDM4EGAAHTTPOLB | |
| SCHEMBL31738422 | 0.66 | TDP1 (0.66) | MAPTKDM4EGAAHTTPOLB | |
| SCHEMBL19955179 | 0.66 | TDP1 (0.66) | MAPTKDM4EGAAHTTPOLB | |
| SCHEMBL28695999 | 0.66 | HDAC4 (0.43) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288898-B1 | SUBSTITUTED CHINOXALYL-IMIDAZOLIDINE-2,4-DIONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACOLOGICAL PREPARATIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-14 | — | — | EP | claimed |
| US-4943576-A | ENZYME INHIBITORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-07-24 | — | — | US | claimed |
| US-4943576-A | ENZYME INHIBITORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-07-24 | — | — | US | disclosed |
| US-4943576-A | ENZYME INHIBITORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-07-24 | — | — | US | disclosed |
| EP-0288898-A1 | Substituted chinoxalyl-imidazolidine-2,4-diones, process for their preparation, their use as medicaments and pharmacological preparations | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-11-02 | — | — | EP | disclosed |