Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.34 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823035 | 0.87 | LMNA (0.51) | LMNAMEN1KMT2ATNKS | |
| SCHEMBL9823335 | 0.79 | LMNA (0.55) | LMNAMEN1KMT2ATNKSMMP2 | |
| SCHEMBL9822749 | 0.76 | LMNA (0.55) | LMNAMEN1KMT2ATNKSMMP2 | |
| SCHEMBL9822728 | 0.74 | TNKS (0.51) | LMNAMEN1KMT2ATNKS | |
| SCHEMBL542678 | 0.72 | LMNA (0.52) | LMNAMEN1KMT2ATNKSMMP2 | |
| SCHEMBL542399 | 0.70 | MEN1 (0.64) | LMNAMEN1KMT2AMMP2MMP9 | |
| SCHEMBL9694252 | 0.68 | KDM4E (0.44) | MEN1KMT2AKCNH2 | |
| SCHEMBL9823155 | 0.68 | CYP2C9 (0.55) | MEN1KMT2ATNKSMMP2MMP9 | |
| SCHEMBL18082993 | 0.67 | NQO2 (0.47) | KMT2AKCNH2 | |
| SCHEMBL18083009 | 0.67 | NQO2 (0.47) | KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288898-B1 | SUBSTITUTED CHINOXALYL-IMIDAZOLIDINE-2,4-DIONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACOLOGICAL PREPARATIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4943576-A | ENZYME INHIBITORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-07-24 | — | — | US | disclosed |