Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300016 | 0.91 | DHFR (0.62) | TYMSDHFR | |
| SCHEMBL9823377 | 0.91 | DHFR (0.71) | TYMSDHFR | |
| SCHEMBL9823464 | 0.90 | DHFR (0.72) | TYMSDHFR | |
| SCHEMBL9823303 | 0.90 | DHFR (0.71) | TYMSDHFR | |
| SCHEMBL9823227 | 0.90 | TYMS (0.60) | TYMSDHFR | |
| SCHEMBL9823079 | 0.90 | DHFR (0.67) | TYMSDHFR | |
| SCHEMBL9823139 | 0.89 | DHFR (0.55) | TYMSDHFR | |
| SCHEMBL15912214 | 0.89 | DHFR (0.59) | TYMSDHFR | |
| SCHEMBL9823090 | 0.88 | DHFR (0.68) | TYMSDHFR | |
| SCHEMBL9298996 | 0.88 | DHFR (0.55) | TYMSDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426666-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-05-15 | — | — | EP | disclosed |
| US-4857530-A | THYMIDYLATE SYNTHASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0316657-A1 | Substituted quinazolinones as anticancer agents | WARNER-LAMBERT COMPANY (US) | 1989-05-24 | — | — | EP | disclosed |
| WO-1989004307-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-05-18 | — | — | WO | disclosed |