Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823220 | 0.84 | LMNA (0.44) | ALDH1A1LMNAPDGFRBSMN1; SMN2MEN1 | |
| SCHEMBL9823347 | 0.68 | PTGER3 (0.36) | LMNANPC1RAB9AMEN1KMT2A | |
| SCHEMBL12878198 | 0.66 | MEN1 (0.39) | LMNAMEN1KMT2ATSHRKDM4E | |
| SCHEMBL6386860 | 0.65 | ALDH1A1 (0.56) | ALDH1A1PDGFRBNPC1RAB9AKDR | |
| SCHEMBL9823023 | 0.65 | ALDH1A1 (0.50) | ALDH1A1PDGFRBNPC1RAB9AKDR | |
| SCHEMBL9823335 | 0.65 | LMNA (0.55) | ALDH1A1LMNAMEN1KMT2ANQO2 | |
| SCHEMBL972751 | 0.64 | MEN1 (0.40) | LMNAMEN1KMT2A | |
| SCHEMBL13388975 | 0.63 | NQO2 (0.72) | ALDH1A1LMNAPDGFRBNPC1RAB9A | |
| SCHEMBL102894 | 0.63 | AKR1B1 (0.36) | LMNAMEN1KMT2AMAPT | |
| SCHEMBL542678 | 0.62 | LMNA (0.52) | ALDH1A1LMNANPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288898-B1 | SUBSTITUTED CHINOXALYL-IMIDAZOLIDINE-2,4-DIONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACOLOGICAL PREPARATIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4943576-A | ENZYME INHIBITORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-07-24 | — | — | US | disclosed |