Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823185 | 0.81 | MEN1 (0.31) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL9823035 | 0.77 | LMNA (0.51) | PTGER3LMNAMEN1KMT2ANPC1 | |
| SCHEMBL9822963 | 0.75 | TNKS (0.43) | PTGER3LMNAMEN1KMT2ATNKS | |
| SCHEMBL9823205 | 0.68 | ALDH1A1 (0.41) | PTGER3LMNAMEN1KMT2ANPC1 | |
| SCHEMBL9822970 | 0.65 | LMNA (0.47) | LMNAMEN1KMT2ATNKS | |
| SCHEMBL1968639 | 0.65 | LMNA (0.61) | PTGER3LMNA | |
| SCHEMBL9823155 | 0.64 | CYP2C9 (0.55) | MEN1KMT2ANPC1RAB9ATNKS | |
| SCHEMBL15973908 | 0.64 | LMNA (0.46) | PTGER3LMNAMEN1KMT2A | |
| SCHEMBL192001 | 0.63 | AKR1B1 (0.44) | PTGER3LMNAMEN1KMT2AKDM4E | |
| SCHEMBL9823335 | 0.63 | LMNA (0.55) | PTGER3LMNAMEN1KMT2ATNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288898-B1 | SUBSTITUTED CHINOXALYL-IMIDAZOLIDINE-2,4-DIONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACOLOGICAL PREPARATIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4943576-A | ENZYME INHIBITORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-07-24 | — | — | US | disclosed |