Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 5/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823234 | 0.96 | TYMS (0.33) | TYMSMEN1POLBTSHRKMT2A | |
| SCHEMBL9823458 | 0.90 | TYMS (0.33) | TYMSMEN1POLBTSHRKMT2A | |
| SCHEMBL9823634 | 0.86 | DHFR (0.43) | TYMS | |
| SCHEMBL9823392 | 0.86 | DHFR (0.40) | TYMSMEN1POLBTSHRKMT2A | |
| SCHEMBL9823173 | 0.83 | CTNNB1 (0.36) | TYMSMEN1POLBTSHRKMT2A | |
| SCHEMBL9823085 | 0.83 | MMP13 (0.41) | MEN1POLBTSHRKMT2ASMN1; SMN2 | |
| SCHEMBL9823478 | 0.82 | DHFR (0.44) | TYMS | |
| SCHEMBL9823207 | 0.81 | DHFR (0.41) | TYMSMEN1POLBTSHRKMT2A | |
| SCHEMBL9823096 | 0.80 | DHFR (0.38) | MEN1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL9823232 | 0.80 | MEN1 (0.36) | TYMSMEN1POLBTSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426666-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-05-15 | — | — | EP | disclosed |
| US-4857530-A | THYMIDYLATE SYNTHASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0316657-A1 | Substituted quinazolinones as anticancer agents | WARNER-LAMBERT COMPANY (US) | 1989-05-24 | — | — | EP | disclosed |
| WO-1989004307-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-05-18 | — | — | WO | disclosed |