Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32666080 | 0.77 | KDM4E (0.69) | KDM4EMAPTALDH1A1POLBHDAC6 | |
| SCHEMBL9728467 | 0.72 | RAB9A (0.72) | KDM4EMAPTALDH1A1TDP1HDAC6 | |
| SCHEMBL1101889 | 0.71 | KDM4E (0.66) | KDM4EMAPTALDH1A1POLBHDAC6 | |
| SCHEMBL9823749 | 0.71 | KDM4E (0.53) | KDM4ECYP3A4KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3818640 | 0.70 | HDAC6 (0.66) | KDM4EMAPTALDH1A1POLBTDP1 | |
| SCHEMBL16629832 | 0.70 | HDAC6 (0.61) | KDM4EMAPTALDH1A1POLBTDP1 | |
| SCHEMBL28658140 | 0.70 | TDP1 (0.62) | KDM4EMAPTALDH1A1POLBTDP1 | |
| SCHEMBL8986856 | 0.69 | KDM4E (1.00) | KDM4EMAPTALDH1A1POLBTDP1 | |
| SCHEMBL22021642 | 0.69 | KDM4E (0.64) | KDM4EMAPTALDH1A1POLBTDP1 | |
| SCHEMBL2990452 | 0.69 | KDM4E (0.64) | KDM4EMAPTALDH1A1POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426666-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-05-15 | — | — | EP | disclosed |
| WO-1989004307-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-05-18 | — | — | WO | disclosed |