Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | UBE2N | P61088 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1520943 | 0.80 | KDM4E (0.60) | KDM4ESMN1; SMN2LMNAKMT2ACYP1A2 | |
| SCHEMBL12411206 | 0.76 | GAA (0.55) | KDM4ESMN1; SMN2LMNAKMT2ACYP1A2 | |
| SCHEMBL27639917 | 0.73 | KDM4E (0.64) | KDM4ELMNAKMT2ACYP1A2MEN1 | |
| SCHEMBL1101889 | 0.71 | KDM4E (0.66) | KDM4ELMNAKMT2ACYP1A2MEN1 | |
| SCHEMBL9823743 | 0.71 | KDM4E (0.64) | KDM4ESMN1; SMN2KMT2ACYP3A4MEN1 | |
| SCHEMBL29405525 | 0.70 | ALDH1A1 (0.72) | SMN1; SMN2LMNAKMT2ACYP1A2CYP3A4 | |
| SCHEMBL6747607 | 0.70 | ALDH1A1 (0.77) | SMN1; SMN2LMNAKMT2ACYP1A2CYP3A4 | |
| SCHEMBL30883267 | 0.69 | KDM4E (1.00) | KDM4ESMN1; SMN2LMNAKMT2ACYP1A2 | |
| SCHEMBL22021637 | 0.69 | KDM4E (0.64) | KDM4ESMN1; SMN2LMNAKMT2ACYP1A2 | |
| SCHEMBL1428216 | 0.69 | KDM4E (1.00) | KDM4ESMN1; SMN2LMNAKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426666-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-05-15 | — | — | EP | disclosed |
| WO-1989004307-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-05-18 | — | — | WO | disclosed |