Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 3/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823277 | 0.89 | P2RX7 (0.42) | P2RX7ABCB11GRIA1GRIA2GRIA4 | |
| SCHEMBL9823549 | 0.88 | P2RX7 (0.43) | P2RX7ABCB11GRIA1GRIA2GRIA4 | |
| SCHEMBL10767597 | 0.77 | MEN1 (0.39) | P2RX7ABCB11GRIA1GRIA2GRIA4 | |
| SCHEMBL14357991 | 0.69 | NR1H2 (0.55) | MEN1KMT2APOLB | |
| SCHEMBL5623433 | 0.68 | P2RX7 (0.46) | P2RX7ABCB11MEN1KMT2APOLB | |
| SCHEMBL6242523 | 0.68 | CNOT7 (0.51) | P2RX7ABCB11MEN1KMT2ATHRB | |
| SCHEMBL6767819 | 0.66 | AKR1B1 (0.46) | ABCB11 | |
| SCHEMBL8603287 | 0.65 | THRB (0.41) | P2RX7ABCB11MEN1KMT2ATHRB | |
| SCHEMBL15741919 | 0.65 | CYP2D6 (0.61) | P2RX7ABCB11MEN1KMT2APOLB | |
| SCHEMBL10766112 | 0.65 | AKR1B1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0232932-B1 | 5,6-DIHYDRO-2-(SUBSTITUTED PHENYL)-1,2,4-TRIAZINE-3,5(2H,4H)-DIONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-02 | — | — | EP | disclosed |
| EP-0232932-A1 | 5,6-Dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-diones | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-08-19 | — | — | EP | disclosed |