Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 6/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9251968 | 0.78 | TSHR (0.50) | TSHRNPSR1 | |
| SCHEMBL11530675 | 0.70 | HDAC3 (0.40) | TSHRNPSR1HDAC3HDAC1HDAC2 | |
| SCHEMBL11795941 | 0.68 | HDAC3 (0.56) | TSHRHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL4974601 | 0.68 | HDAC3 (0.61) | TSHRHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL9824431 | 0.68 | TSHR (0.57) | TSHRNPSR1 | |
| SCHEMBL14660479 | 0.67 | TSHR (0.52) | TSHRNPSR1DDB1CRBN | |
| SCHEMBL22482041 | 0.67 | HDAC3 (0.46) | TSHRHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL9304202 | 0.67 | SIGMAR1 (0.46) | MAOBACHESIGMAR1 | |
| SCHEMBL9824805 | 0.66 | TSHR (0.55) | TSHRNPSR1 | |
| Hydrochloric Acid SCHEMBL9824043 | 0.66 | TSHR (0.55) | TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0199963-B1 | ETHOSUXIMIDE ASSAY TRACERS, IMMUNOGENS AND ANTIBODIES | ABBOTT LABORATORIES (US) | 1991-10-23 | — | — | EP | disclosed |
| EP-0199963-A1 | Ethosuximide assay tracers, immunogens and antibodies | ABBOTT LABORATORIES (US) | 1986-11-05 | — | — | EP | disclosed |