Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ADH1B | P00325 | 1/20 | 0.31 |
| ▸ | ADH1C | P00326 | 1/20 | 0.31 |
| ▸ | ADH1A | P07327 | 1/20 | 0.31 |
| ▸ | ADH4 | P08319 | 1/20 | 0.31 |
| ▸ | ADH7 | P40394 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3893332 | 0.78 | CFB (0.38) | HRH3OPRM1OPRL1ALDH1A1L3MBTL1 | |
| SCHEMBL9824830 | 0.75 | GNAI3 (0.36) | HRH3CXCR4ALDH1A1ADH1BADH1C | |
| SCHEMBL10567089 | 0.74 | DPP4 (0.37) | OPRM1OPRL1ALDH1A1CTSBCTSS | |
| SCHEMBL9824726 | 0.73 | CHRM5 (0.41) | HRH3OPRM1OPRL1 | |
| SCHEMBL10699421 | 0.72 | POLB (0.42) | HRH3L3MBTL1 | |
| SCHEMBL3895146 | 0.72 | POLB (0.42) | HRH3L3MBTL1 | |
| SCHEMBL9824416 | 0.71 | CHRM5 (0.44) | HRH3OPRM1OPRL1 | |
| SCHEMBL9825059 | 0.71 | CHRM5 (0.44) | HRH3OPRM1OPRL1 | |
| SCHEMBL4293383 | 0.71 | OPRM1 (0.37) | OPRM1OPRL1 | |
| SCHEMBL9824968 | 0.71 | CXCR4 (0.43) | HRH3CXCR4ADH1BADH1CADH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |