Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825059 | 1.00 | CHRM5 (0.44) | CHRM5ADRA2CSIGMAR1HRH3CYP1A2 | |
| SCHEMBL9824726 | 0.98 | CHRM5 (0.41) | CHRM5ADRA2CSIGMAR1HRH3CYP1A2 | |
| SCHEMBL9824023 | 0.87 | SIGMAR1 (0.35) | CHRM5ADRA2CSIGMAR1HRH3CYP1A2 | |
| SCHEMBL9824186 | 0.79 | MAPT (0.46) | HRH3CYP1A2MAPT | |
| SCHEMBL3893332 | 0.78 | CFB (0.38) | HRH3OPRM1OPRL1 | |
| SCHEMBL17570423 | 0.76 | CHRM5 (0.65) | CHRM5ADRA2CSIGMAR1HRH3CYP1A2 | |
| SCHEMBL8443502 | 0.76 | CHRM5 (0.48) | CHRM5ADRA2CSIGMAR1HRH3CYP1A2 | |
| SCHEMBL4293383 | 0.75 | OPRM1 (0.37) | CYP1A2OPRM1OPRL1 | |
| SCHEMBL9824397 | 0.73 | CHRM5 (0.45) | CHRM5ADRA2CSIGMAR1HRH3CYP1A2 | |
| SCHEMBL9824102 | 0.73 | CHRM5 (0.45) | CHRM5ADRA2CSIGMAR1HRH3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |