Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10770013 | 0.91 | LMNA (0.43) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9825107 | 0.90 | LMNA (0.53) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9824535 | 0.84 | KMT2A (0.45) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9824938 | 0.83 | ALDH1A1 (0.37) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9824797 | 0.82 | TNKS (0.39) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9824741 | 0.81 | KDM4E (0.46) | PIM1PIM2GSK3APIM3DRD3 | |
| SCHEMBL9824269 | 0.80 | LMNA (0.42) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9824932 | 0.80 | DRD3 (0.50) | LMNAPIM1PIM2GSK3APIM3 | |
| SCHEMBL9824213 | 0.78 | PIM1 (0.40) | PIM1PIM2GSK3APIM3DRD3 | |
| SCHEMBL10576387 | 0.74 | PIM1 (0.35) | PIM1PIM2GSK3APIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227088-B1 | ISOXAZOLO-NAPHTHYRIDINE, ISOXAZOLO QUINOLINE, ISOTHIAZOLONAPHTHYRIDINE, AND ISOTHIAZOLOQUINOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4767762-A | Tricyclic quinoline and naphthyride antibacterials | ABBOTT LABORATORIES (US) | 1988-08-30 | — | — | US | disclosed |
| EP-0227088-A1 | Isoxazolo-naphthyridine, isoxazolo quinoline, isothiazolonaphthyridine, and isothiazoloquinoline derivatives | ABBOTT LABORATORIES (US) | 1987-07-01 | — | — | EP | disclosed |