Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824726 | 0.89 | CHRM5 (0.41) | SIGMAR1CYP1A2OPRM1OPRL1CHRM5 | |
| SCHEMBL9824416 | 0.87 | CHRM5 (0.44) | SIGMAR1CYP1A2OPRM1OPRL1CHRM5 | |
| SCHEMBL9825059 | 0.87 | CHRM5 (0.44) | SIGMAR1CYP1A2OPRM1OPRL1CHRM5 | |
| SCHEMBL9824908 | 0.76 | KEAP1 (0.42) | SIGMAR1CYP1A2UTS2RCHRM5ADRA2C | |
| SCHEMBL4714209 | 0.76 | SIGMAR1 (0.49) | SIGMAR1CYP1A2CHRM5ADRA2CGAA | |
| SCHEMBL18875532 | 0.73 | ALDH1A1 (0.41) | SIGMAR1GAAHRH3 | |
| SCHEMBL3893332 | 0.73 | CFB (0.38) | OPRM1OPRL1HRH3 | |
| SCHEMBL13634807 | 0.71 | CYP1A2 (0.50) | CYP1A2CHRM5ADRA2CTP53 | |
| SCHEMBL18878815 | 0.71 | SIGMAR1 (0.42) | SIGMAR1CYP1A2GAAHRH3 | |
| SCHEMBL4293383 | 0.70 | OPRM1 (0.37) | CYP1A2OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |