Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 5/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 2/20 | 0.30 |
| ▸ | DRD3 | P35462 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824823 | 0.90 | MEN1 (0.32) | MEN1KMT2A | |
| SCHEMBL9824395 | 0.89 | MEN1 (0.34) | MEN1KMT2AL3MBTL1MAOBKDM2B | |
| SCHEMBL13036986 | 0.82 | KDM2B (0.38) | MAOBKDM2BBCHEDRD2DRD3 | |
| SCHEMBL9824437 | 0.81 | MAOB (0.34) | MEN1KMT2AMAOBKDM2BBCHE | |
| SCHEMBL9824895 | 0.81 | DRD2 (0.34) | MAOBDRD2DRD3 | |
| SCHEMBL9824779 | 0.76 | KMT2A (0.46) | MEN1KMT2AL3MBTL1BCHE | |
| SCHEMBL13006566 | 0.76 | MEN1 (0.40) | MEN1KMT2AL3MBTL1DRD3 | |
| SCHEMBL4387050 | 0.75 | KDM2B (0.38) | MAOBKDM2BBCHEDRD2DRD3 | |
| SCHEMBL665119 | 0.75 | MAOB (0.38) | MAOBKDM2BBCHEDRD2DRD3 | |
| SCHEMBL3897140 | 0.75 | CYP2D6 (0.44) | MAOBKDM2BBCHEDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |