Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824395 | 0.92 | MEN1 (0.34) | DRD2DRD3MAOB | |
| SCHEMBL9824823 | 0.90 | MEN1 (0.32) | PGR | |
| SCHEMBL9824712 | 0.81 | MEN1 (0.40) | DRD2DRD3MAOB | |
| SCHEMBL9823863 | 0.77 | GNAI3 (0.42) | DRD2DRD3 | |
| SCHEMBL9824965 | 0.75 | HRH3 (0.33) | PGR | |
| SCHEMBL11470499 | 0.73 | DRD2 (0.41) | DRD2DRD3 | |
| SCHEMBL1307015 | 0.72 | DRD3 (0.46) | DRD2DRD3 | |
| SCHEMBL597477 | 0.72 | MAOB (0.36) | MAOAMAOB | |
| SCHEMBL13036986 | 0.70 | KDM2B (0.38) | DRD2DRD3MAOB | |
| SCHEMBL25565978 | 0.70 | NCF1 (0.36) | DRD2DRD3PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |