Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | MME | P08473 | 3/20 | 0.52 |
| ▸ | ACE | P12821 | 2/20 | 0.52 |
| ▸ | CPA1 | P15085 | 2/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.52 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | PYGL | P06737 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824719 | 1.00 | POLB (0.53) | POLBCASP6MMEACECPA1 | |
| SCHEMBL6349086 | 0.82 | CNR2 (0.73) | POLBCASP6MMEACECPA1 | |
| SCHEMBL7361590 | 0.77 | ALDH1A1 (0.50) | POLBMMEACECPA1ACE2 | |
| SCHEMBL31661673 | 0.77 | CNR2 (0.72) | POLBCNR2KMT2ANOD1 | |
| SCHEMBL4745190 | 0.77 | P2RY14 (0.54) | POLBACEKMT2A | |
| SCHEMBL6789997 | 0.75 | KMT2A (0.56) | KMT2ACYP2C9RAB9A | |
| SCHEMBL8352136 | 0.74 | MME (0.43) | POLBMMEACECPA1ACE2 | |
| SCHEMBL9354646 | 0.74 | CNR2 (0.57) | POLBMMEACECPA1ACE2 | |
| SCHEMBL7449907 | 0.74 | MME (0.50) | POLBCASP6MMEACECPA1 | |
| SCHEMBL7689184 | 0.74 | PYGL (0.46) | KMT2APYGLFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305492-A4 | PHOSPHOLIPASE A 2? INHIBITORS | — | 1991-09-04 | — | — | EP | disclosed |
| EP-0305492-A1 | PHOSPHOLIPASE A 2? INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-03-08 | — | — | EP | disclosed |
| US-4792555-A | DESENSITIZERS; ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-12-20 | — | — | US | disclosed |
| WO-1988006885-A1 | PHOSPHOLIPASE A2 INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-09-22 | — | — | WO | disclosed |