Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8353758 | 0.87 | CASP3 (0.46) | MMEACECPA1ACE2PSMB5 | |
| SCHEMBL8356020 | 0.83 | CASP3 (0.47) | MMEACECPA1ACE2PSMB5 | |
| SCHEMBL7201963 | 0.74 | CASP3 (0.48) | MMEACECPA1ACE2PSMB5 | |
| SCHEMBL7201964 | 0.74 | CASP3 (0.48) | MMEACECPA1ACE2PSMB5 | |
| SCHEMBL9824722 | 0.74 | POLB (0.53) | MMEACECPA1ACE2PSMB5 | |
| SCHEMBL9824719 | 0.74 | POLB (0.53) | MMEACECPA1ACE2PSMB5 | |
| SCHEMBL14598409 | 0.69 | CASP3 (0.58) | POLBKDM4EALDH1A1RENLMNA | |
| SCHEMBL7204618 | 0.69 | CASP3 (0.59) | — | |
| SCHEMBL8356276 | 0.69 | CASP3 (0.57) | MMEACECPA1ACE2LMNA | |
| SCHEMBL6374657 | 0.68 | MEN1 (0.48) | MMEACECPA1ACE2PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003072528-A2 | (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | IDUN PHARMACEUTICALS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |