Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 8/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827156 | 0.84 | TGM2 (0.49) | TGM2LMNASMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL4598760 | 0.78 | TGM2 (0.45) | TGM2LMNASMN1; SMN2TSHRITGB3 | |
| SCHEMBL4934061 | 0.75 | TGM2 (0.49) | TGM2ITGB3ITGA2B | |
| SCHEMBL4934993 | 0.75 | TGM2 (0.49) | TGM2ITGB3ITGA2B | |
| SCHEMBL4598577 | 0.74 | TGM2 (0.44) | TGM2SMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL9201637 | 0.73 | CHRM1 (0.42) | LMNASMN1; SMN2TSHR | |
| SCHEMBL4598860 | 0.72 | TGM2 (0.42) | TGM2LMNASMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL9826313 | 0.72 | TGM2 (0.42) | TGM2ITGB3ITGA2B | |
| SCHEMBL9825676 | 0.72 | TGM2 (0.47) | TGM2TSHRITGB3ITGA2B | |
| SCHEMBL4950332 | 0.71 | TGM2 (0.47) | TGM2TSHRITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | claimed |
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |