Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPRA | P18433 | 1/20 | 0.43 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | PPIA | P62937 | 2/20 | 0.37 |
| ▸ | STK17B | O94768 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9826395 | 0.89 | MAPT (0.43) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL9826042 | 0.87 | LRRK2 (0.40) | SGMS2MEN1KMT2ALRRK2CSNK2A2 | |
| SCHEMBL9825641 | 0.85 | HPGD (0.44) | PTPN1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9827854 | 0.82 | L3MBTL1 (0.40) | PTPN1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL11560468 | 0.77 | MET (0.52) | SGMS2LRRK2NOX1 | |
| SCHEMBL11563381 | 0.76 | LRRK2 (0.55) | SGMS2KDM4EALDH1A1MAPTLRRK2 | |
| SCHEMBL11555954 | 0.76 | LRRK2 (0.54) | SGMS2LRRK2NOX1 | |
| SCHEMBL9377138 | 0.76 | SENP5 (0.47) | KDM4EALDH1A1NOX1 | |
| SCHEMBL11561500 | 0.75 | LRRK2 (0.63) | SGMS2KMT2ALRRK2PTGER1 | |
| SCHEMBL11563128 | 0.75 | LRRK2 (0.63) | SGMS2MEN1KMT2ALRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0249236-B1 | N-1H-TETRAZOL-5-YL-(5-RING)-CARBOXAMIDE-DERIVATIVES, A PROCESS FOR THEIR MANUFACTURE, AND THE USE THEREOF | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | claimed |
| US-4748183-A | N-1H-tetrazol-5-yl-2-thiophene carboxamides, N-1H-tetrazol-5-yl-2-pyrrole carboxamides, N-1H-tetrazol-5-yl-2-furan carboxamides, and anti-allergic and anti-inflammatory use thereof | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | claimed |
| EP-0249236-A1 | N-1H-Tetrazol-5-yl-(5-Ring)-carboxamide-derivatives, a process for their manufacture, and the use thereof | WARNER-LAMBERT COMPANY (US) | 1987-12-16 | — | — | EP | claimed |