Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30802401 | 0.73 | HTR2C (0.52) | NAAALMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL23130617 | 0.73 | HTR2C (0.52) | NAAALMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL31612922 | 0.72 | LMNA (0.43) | NAAALMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL7788793 | 0.72 | GBA2 (0.51) | NAAALMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL8445034 | 0.71 | ACE (0.48) | LMNASMN1; SMN2POLBALDH1A1BCHE | |
| SCHEMBL10434958 | 0.71 | ACE (0.48) | LMNASMN1; SMN2POLBALDH1A1BCHE | |
| SCHEMBL28877769 | 0.70 | LMNA (0.47) | NAAALMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL30749031 | 0.70 | LMNA (0.41) | NAAALMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL22144158 | 0.70 | LMNA (0.45) | NAAALMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL30118071 | 0.69 | LMNA (0.43) | NAAALMNASMN1; SMN2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0440670-A1 | HETEROCYCLIC ACETYLENIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY. | UPJOHN CO (US) | 1991-08-14 | — | — | EP | disclosed |
| WO-1990004588-A1 | HETEROCYCLIC ACETYLENIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1990-05-03 | — | — | WO | disclosed |