Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.70 |
| ▸ | HTR1A | P08908 | 5/20 | 0.60 |
| ▸ | HRH1 | P35367 | 4/20 | 0.58 |
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2485756 | 0.84 | TDP1 (0.58) | HRH3HRH1HTR2ARAB9AMAPT | |
| SCHEMBL9826692 | 0.84 | DRD2 (0.55) | DRD3HRH3HTR1AHRH1HTR2A | |
| SCHEMBL1101138 | 0.84 | KDM4E (0.58) | RAB9AMAPTNPC1 | |
| SCHEMBL1101056 | 0.83 | HRH3 (0.58) | HRH3HRH1HTR2ARAB9AMAPT | |
| SCHEMBL11826635 | 0.82 | HRH3 (1.00) | DRD3HRH3HTR1AHRH1HTR2A | |
| SCHEMBL2486100 | 0.81 | RAB9A (0.52) | HTR2ARAB9AMAPTHTR2CNPC1 | |
| SCHEMBL2483050 | 0.81 | TDP1 (0.64) | HRH3HRH1HTR2ARAB9AMAPT | |
| SCHEMBL9825581 | 0.80 | HRH3 (0.76) | DRD3HRH3HTR1AHRH1HTR2A | |
| SCHEMBL2481096 | 0.80 | KDM4E (0.53) | RAB9AMAPTNPC1 | |
| SCHEMBL2486394 | 0.80 | HRH3 (0.64) | HRH3HRH1HTR2ARAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237781-B1 | PHENYL AND HETEROCYCLIC TETRAHYDROPYRIDYL AND PIPERAZINYL ALKOXY-BENZHETEROCYCLIC COMPOUNDS AS ANTIPSYCHOTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | claimed |