Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.55 |
| ▸ | HTR1A | P08908 | 5/20 | 0.55 |
| ▸ | HTR2A | P28223 | 4/20 | 0.55 |
| ▸ | DRD1 | P21728 | 3/20 | 0.55 |
| ▸ | DRD3 | P35462 | 3/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.53 |
| ▸ | DRD5 | P21918 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2483050 | 0.87 | TDP1 (0.64) | HTR2AHRH3NPC1RAB9AADRA1A | |
| SCHEMBL2481096 | 0.86 | KDM4E (0.53) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL2486394 | 0.86 | HRH3 (0.64) | HTR2AHRH3NPC1RAB9AADRA1A | |
| SCHEMBL9826331 | 0.84 | DRD3 (0.70) | DRD2HTR1AHTR2ADRD3HRH3 | |
| SCHEMBL2485756 | 0.83 | TDP1 (0.58) | HTR2AHRH3NPC1RAB9AADRA1A | |
| SCHEMBL1101138 | 0.82 | KDM4E (0.58) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL1101056 | 0.82 | HRH3 (0.58) | HTR2AHRH3NPC1RAB9AADRA1A | |
| SCHEMBL9825874 | 0.81 | HTR2A (0.54) | DRD2HTR1AHTR2ADRD1DRD3 | |
| SCHEMBL2486100 | 0.80 | RAB9A (0.52) | HTR2ANPC1RAB9AMEN1KMT2A | |
| SCHEMBL10654773 | 0.79 | RAB9A (0.56) | DRD2HTR1ADRD3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237781-B1 | PHENYL AND HETEROCYCLIC TETRAHYDROPYRIDYL AND PIPERAZINYL ALKOXY-BENZHETEROCYCLIC COMPOUNDS AS ANTIPSYCHOTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | claimed |