Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | SLC15A1 | P46059 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6671876 | 0.78 | SLC15A1 (0.43) | LTA4HSLC15A1KMT2AALDH1A1ABCB1 | |
| SCHEMBL3958174 | 0.77 | HCAR2 (0.45) | HCAR2KMT2ASMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL22844787 | 0.76 | ALDH1A1 (0.49) | HCAR2KMT2ASMN1; SMN2ALDH1A1ABCB1 | |
| SCHEMBL10901317 | 0.75 | SLC15A1 (0.43) | LTA4HSLC15A1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11280290 | 0.75 | SLC15A1 (0.43) | LTA4HSLC15A1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4893004 | 0.74 | HCAR2 (0.49) | HCAR2KMT2AALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL7314530 | 0.74 | SLC15A1 (0.51) | LTA4HSLC15A1ALDH1A1ABCB1SLC1A3 | |
| SCHEMBL7314517 | 0.74 | SLC15A1 (0.51) | LTA4HSLC15A1ALDH1A1ABCB1SLC1A3 | |
| SCHEMBL541750 | 0.74 | HCAR2 (0.51) | HCAR2KMT2AALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL169622 | 0.74 | LTA4H (0.54) | LTA4HSLC15A1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |