Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | NAAA | Q02083 | 1/20 | 0.58 |
| ▸ | PLK1 | P53350 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | THRA | P10827 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13593264 | 0.85 | ALOX15 (0.70) | ALOX15LMNATP53HTTNPC1 | |
| SCHEMBL29229439 | 0.85 | TRPV1 (0.56) | ALOX15PLK1TRPV1THRATHRB | |
| SCHEMBL5656623 | 0.84 | ALOX15 (0.72) | ALOX15LMNATP53HTTNPC1 | |
| SCHEMBL19077953 | 0.84 | ALOX15 (0.68) | ALOX15LMNATP53HTTNPC1 | |
| SCHEMBL9827313 | 0.83 | PLAU (0.58) | ALOX15PLK1TRPV1THRATHRB | |
| SCHEMBL13293963 | 0.83 | NPC1 (0.70) | ALOX15LMNATP53HTTNPC1 | |
| SCHEMBL5497568 | 0.83 | KAT8 (0.64) | ALOX15LMNATP53HTTNPC1 | |
| SCHEMBL6381563 | 0.82 | ALOX15 (0.70) | ALOX15LMNATP53HTTNPC1 | |
| Hydrochloric Acid SCHEMBL10386190 | 0.81 | ALOX15 (0.55) | ALOX15THRATHRBCA12CA1 | |
| SCHEMBL28134780 | 0.81 | ALOX15 (0.68) | ALOX15LMNATP53HTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221346-B1 | (N-SUBSTITUTED-2-HYDROXY) BENZAMIDES AND N-SUBSTITUTED-2-HYDROXY-ALPHA-OXO-BENZENEACETAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF HAVING ACTIVITY AS MODULATORS OF THE ARACHIDONIC ACID CASCADE | WARNER-LAMBERT COMPANY (US) | 1991-01-30 | — | — | EP | disclosed |
| EP-0221346-A1 | (N-substituted-2-hydroxy) benzamides and N-substituted-2-hydroxy-alpha-oxo-benzeneacetamides and pharmaceutical compositions thereof having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |